CHSJ

Curr Health Sci J, vol. 39, no. 2, 2013

Cellular Basis of Bronchial Inflammation in Chronic Obstructive Pulmonary Disease (COPD)

[Review]

F. PETRESCU(1), V. BICIUSCA(1), O.I. PETRESCU(2), C.M. FORTOFOIU(1)


(1)Department of Medical Semiology, University of Medicine and Pharmacy, Craiova;
(2)Department of Pediatrics, County Hospital Emergency, University of Medicine and Pharmacy, Craiova


Abstract:

Chronic obstructive pulmonary disease (COPD) is a major health problem, characterized by a progressively and irreversible change in lung function. This is associated with chronic airways inflammation, structural remodeling, and alveolar wall destruction. Inflammatory cells may contribute to mucus hypersecretion, the airways remodeling by the secretion of proteases, cytokines, and fibrotic or mitogenic growth factors. Neutrophils, macrophages, and T cells have implicated in many studies, indicating their roles in the chronic inflammatory process of airways. The identification of risk factors, inflammatory mediators, and understanding their interactions are important for the development of anti-inflammatory treatments, that may reduce the inflammation and alleviate the clinical symptoms of COPD.


Keywords: inflammatory cells, inflammation, Chronic Obstructive Pulmonary Disease (COPD)



Corresponding: Conf. Univ. Dr. Florin Petrescu, Second Medical Clinic, County Hospital of Emergency, Tabaci Street, no1, University of Medicine and Pharmacy, Petru Rares Street, no 2, Craiova, Dolj, e-mail: semio@umfcv.ro


DOI 10.12865/CHSJ.39.02.01 - Download PDF
current issue cover Download cover
Download contents

Journal archive