Curr Health Sci J, vol. 39, no. 3, 2013

Antipsychotic Drugs And Salivary Leptin Levels In Wistar Rats

[Original Paper]

MARIA BOGDAN1, ANCA BERBECARU-IOVAN1, CRISTINA DUMITRESCU1, CATALINA PISOSCHI2, A. CAMEN3

1Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova 2Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova 3Department of Oral and Maxillo-Facial Surgery, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova


Abstract:

Purpose. Mental dissorders such as psychosis, agitation, mania, dementia and bipolar disorder are treated with variable doses of antipsychotics. However, these drugs are often associated with metabolic side effects (weight gain), endocrine disruptions, diabetes mellitus and cardiovascular diseases.Unfortunately, a single reliable predictor of weight gain has not been found, but a relation is to be mentioned between the levels of circulating leptin, administration of antipsychotics and weight increase. The aim of this study was to assess the effects of exposure to antipsychotics from both generations on the salivary leptin levels. Material and Methods. Salivary leptin was determined by the ELISA technique, on three groups of male Wistar rats treated with haloperidole, haloperidole decanoate and aripiprazole for 4 weeks.Results. The present study evidences a significant statistical difference between the values of salivary leptin prior to and after the drug treatment with the first generation agents. Aripiprazole produced no changes. Conclusions. The treatment with haloperidole and haloperidole decanoate induces an increase in salivary leptin levels.


Keywords:
antipsychotics, rats, salivary leptin, weight gain



Corresponding:
Antipsychotic Drugs And Salivary Leptin Levels In Wistar Rats


DOI 10.12865/CHSJ.39.03.06 - Download PDF