Curr Health Sci J, vol. 39, no. 4, 2013

Probiotics and Their Immunomodulatory Potential



(1)University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania,
(3)University of Medicine and Pharmacy of Craiova, Pediatric Clinic, Filantropia County Hospital of Craiova, Romania


The definition of probiotics has evolved from a live active culture which improves the balance of the gut microbiota composition to specific effects, in particular, the immunomodulatory potential of clearly defined strains. The strains with beneficial properties, potential sources of probiotics, most frequently belong to the genera Bifidobacterium and Lactobacillus, and some of these strains exhibit powerful anti-inflammatory properties. These effects are attributed to the normal restoration of increased intestinal permeability and unbalanced gut microbiota, improvement of the intestineÃ�A¢Ã¯A¿A½Ã¯A¿A½s immunological barrier functions and alleviation of the intestinal inflammatory response. The application of probiotics in pediatric practice currently lies in enhancing these barrier functions in the gut and reducing the risk of diseases associated with their dysfunction. The most fully documented probiotic intervention is the treatment and prevention of acute infectious diarrhea.

probiotic, intestinal microflora, immune modulation, inflammation

Liana VIasu-Bolocan, MD, PhD Student, Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Str. Petru Rares No 4, 200456, Craiova, Romania, e-mail:

DOI 10.12865/CHSJ.39.04.02 - Download PDF