CHSJ

Curr Health Sci J, vol. 40, no. 1, 2014

Plasma Levels of Glucose and Insulin in Patients with Brain Tumors

[Original Paper]

OANA ALEXANDRU(1), L. ENE(1), OANA STEFANA PURCARU(2), DANIELA ELISE TACHE(2), ALISA POPESCU(2), OANA MARIA NEAMTU(3), LIGIA GABRIELA TATARANU(4), ADA MARIA GEORGESCU(5), VALERICA TUDORICA(1), CORNELIA ZAHARIA(1), ANICA DRICU(2)


(1)University of Medicine and Pharmacy Craiova, Department of Neurology, Romania,
(2)University of Medicine and Pharmacy Craiova, Department of Biochemistry, Romania,
(3)University of Craiova, Department of Sports Medicine and Kinesiology, Romania,
(4)Bagdasar-Arseni Hospital, Department of Neurosurgery, Bucharest, Romania,
(5)Medico Science Romania


Abstract:

In the last years there were many authors that suggest the existence of an association between different components of metabolic syndrome and various cancers. Two important components of metabolic syndrome are hyperglycemia and hyperinsulinemia. Both of them had already been linked with the increased risk of pancreatic, breast, endometrial or prostate cancer. However the correlation of the level of the glucose and insulin with various types and grades of brain tumors remains unclear. In this article we have analysed the values of plasma glucose and insulin in 267 patients, consecutively diagnosed with various types of brain tumors. Our results showed no correlation between the glycemia and brain tumor types or grades. High plasma levels of insulin were found in brain metastasis and astrocytomas while the other types of brain tumors (meningiomas and glioblastomas) had lower levels of the peptide. The levels of insulin were also higher in brain metastasis and grade 3 brain tumors when compared with grade 1, grade 2 and grade 4 brain tumors.


Keywords: brain tumors, relations, glucose, insulin



Corresponding: Anica Dricu; Department of Biochemistry University of Medicine and Pharmacy Craiova, , Romania, Petru Rares St., No. 2-4, Craiova 200349, Romania; e-mail: anica.dricu@webmail.umfcv.ro, anica.dricu@live.co.uk


DOI 10.12865/CHSJ.40.01.05 - Download PDF
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