CHSJ

Curr Health Sci J, vol. 40, no. 4, 2014

Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

[Original Paper]

V. PADUREANU(1), IOANA STREATA(1), M. IOANA(1), V. SURLIN(1), E.F. GEORGESCU(1), C. MARGINEAN(1), A. SAFTOIU(1)


(1)Research Center of Gastroenterology and Hepatology, Craiova, Romania


Abstract:

Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS – 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated. Results: We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis. Conclusion: In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.


Keywords: acute pancreatitis, polymorphism, genotype, iNOS



Corresponding: Adrian Saftoiu, MD, PhD, MSc, FASGE Visiting Clinical Professor, Gastrointestinal Unit, Copenhagen University Hospital Herlev, DENMARK; Professor of Diagnostic and Therapeutic Techniques in Gastroenterology, Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, ROMANIA address: 2 Petru Rares str., Craiova, Dolj, 200349, ROMANIA; mobile: + 40 744 823355 and fax: +40 0251 310287; e-mail: adrian.saftoiu@umfcv.ro or adriansaftoiu@aim.com


DOI 10.12865/CHSJ.40.04.03 - Download PDF
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