CHSJ

Curr Health Sci J, vol. 40, no. 4, 2014

Pharmacokinetic profile evaluation of di-?-hydroxo-bis (quercetinatooxovanadium(IV)) complex

[Original Paper]

B.S. VELESCU(1), V. UIVAROSI(1), A. BUZESCU(1), I. SARBU(1), E. IONESCU(2), V. ANUTA(1)


(1)”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy;
(2)”Carol Davila” University of Medicine and Pharmacy, Faculty of Dental Medicine


Abstract:

The present study was designed to evaluate the pharmacokinetic (PK) properties of di-?-hydroxo-bis(quercetinatooxovanadium(IV) (HOBQOV) complex, with hypoglycemic and hypolipidemic properties, in rats after a single i.p. dose of 100 mg/kg b.w. The HOBQOV complex pharmacokinetics is described by a bicompartmental model and the plasma concentration decrease is described by two phases that might be correlated to the distribution and elimination processes. The obtained results suggest a PK profile of the complex suitable for a profound distribution in the animal organism with possibility of interaction with the cytosolic enzymes.


Keywords: HOBQOV, HPLC, pharmacokinetics, bicompartmental model



Corresponding: Valentina Uivarosi, "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Department General and Inorganic Chemistry, 6 Traian Vuia Str., 020956, Bucharest, Romania; tel.: +40740593237; e-mail: valentina_uivarosi@yahoo.com


DOI 10.12865/CHSJ.40.04.06 - Download PDF
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