CHSJ

Curr Health Sci J, vol. 40, no. 4, 2014

Lung Involvement in Multiple Myeloma - Case Study

[Case Reports]

M. NITU(1), E. CRISAN(1), M. OLTEANU(1), C. CALARASU(2), M. OLTEANU(1), M.R. POPESCU(1)


(1)University of Medicine and Pharmacy, Craiova, Pneumology Department;
(2)“Victor Babes” Hospital of Infectious Diseases and Pneumology, Craiova


Abstract:

Introduction: Mutiple mieloma (MM) cells are rarely found in extramedullary sites. The sites of extramedullary dissemination reported in the literature are spleen, liver, lymph nodes, kidneys, thyroid gland, adrenal gland, ovary, tests, lung, pleura, pericardium, intestinal tract and skin. We report a case in which the myeloma was diagnosed after we discovered the presence of monoclonal plasma cells in the bronchoalveolar lavage fluid (BAL). Matherial and method: a case in which diagnosis was established from bronchoalveolar lavage (BAL) fluid demonstrating the presence of monoclonal plasma cells in Craiova Pneumology Departament. Results: Analysis of BAL fluid for the presence of plasma cells and for cytoplasmic immunoglobulin DNA provides a noninvasive means of establishing the diagnosis. Conclusions: Pulmonary parenchyma is an uncommon site of extramedullary involvement in multiple myeloma. Interstitial lung disease as pulmonary manifestation of multiple myeloma is even rarer; only isolated cases with histological proofs have been reported in the literature.


Keywords: multiple myeloma, myelomatous pulmonary infiltrate, lung fibrosis



Corresponding: Mimi Nitu, MD PhD, University of Medicine and Pharmacy of Craiova, Pneumology Department , "Victor Babes" Hospital of Infectious Diseases and Pneumology, Craiova, Calea Bucuresti, No. 126; e-mail: dr_nitumimi@yahoo.com


DOI 10.12865/CHSJ.40.04.08 - Download PDF
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