CHSJ

Curr Health Sci J, vol. 41, no. 2, 2015

Statistical Correlations of the Spontaneous Abortion with Trombophilia and Other Associated Pathologies

[Original Paper]

MAGDALENA MARIA MANOLEA(1), ANDA LORENA DIJMARESCU(1), SIMONA NEAMTU(1), D.O. ALEXANDRU(1), R. RICA(1), A. GOGANAU(1), LILIANA NOVAC(1)


(1)university of medicine and pharmacy of craiova


Abstract:

15-20% of all known pregnancies progress with a miscarriage or an ectopic pregnancy. The recurrent miscarriage is a delicate clinical situation because with all the advances in genetic and immunologic research the incriminating factors have not been discovered yet. The treatment is also subject to controversies, being perceived as either ineffective or aggressive. A number of 376 pregnant women with a gestational age smaller than 12 weeks have been selected, 226 of them with spontaneous abortion. In the study group of patients with previous spontaneous abortions we have found a series of associated pathology. From the cases with secondary non idiopathic recurrent miscarriage we have identified 4 cases of thrombophilia with antiphospholipid syndrome, 2 cases of thrombocytosis, one case of autoimmune thyroiditis, one case of uterine tumor, one case of MTHFR C homozygous thrombophilia and one case of FVL heterozygous thrombophilia. Knowing the correlations between the recurrent miscarriage and the hereditary thrombophilia as well as the options of treatment for increasing the chances of having a pregnancy with a normal evolution direct the doctors in testing the patients with recurrent miscarriage for hereditary thrombophilia.


Keywords: recurrent miscarriage, trombophilia, associated diseases



Corresponding: Maria Magdalena Manolea, MD, PhD, Lecturer, Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, 2-4 Petru Rares Street, 200349 Craiova, Romania; e-mail: manoleamaria@gmail.com


DOI 10.12865/CHSJ.41.02.11 - Download PDF
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