CHSJ

Curr Health Sci J, vol. 41, no. 3, 2015

Particularities of Renal Manifestations in Chronic Viral Hepatitis

[Original Paper]

V.F. IOVANESCU(1), C.T. STREBA(2), D.O. ALEXANDRU(3), A.F. CONSTANTINESCU(1), C.C. VERE(2), I. ROGOVEANU(2), E. MOTA(4)


(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania;
(2)Gastroenterology Department, University of Medicine and Pharmacy of Craiova, Romania;
(3)Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania;
(4)Department of Nephrology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Introduction: Chronic viral hepatitis represent major health problems worldwide, with an evolution that is sometimes marked by a series of extrahepatic manifestations. Among these, kidney disease may occur, either as glomerulonephritis, and/or renal dysfunction. Material and methods: The purpose of this study was to achieve a complete assessment of the liver and kidney function in a series of patients diagnosed with chronic viral hepatitis, in order to identify a possible kidney disease in this context. 104 patients with chronic viral hepatitis B and C, aged between 25 and 80, were included in the study. These patients were assessed by a series of tests that allowed us to perform a complete evaluation of both liver and kidney function: liver cytolysis enzymes, serum bilirubin, markers of cholestasis, markers of viral infection, urinalysis, albuminuria, electrophoresis of urinary proteins, urea, creatinine, and abdominal ultrasound. Results: Glomerular injury was a rare finding in patients with chronic hepatitis. Patients with chronic hepatitis B had glomerular disease in 5,88 % of cases, while 10 % of the patients with hepatitis C presented this type of renal disease. Acute kidney injury was not identified in our patient group. None of the patients in the hepatitis B study group presented chronic kidney disease. CKD was present in two patients with chronic hepatitis C that had no other associated conditions.


Keywords: chronic hepatitis B, chronic hepatitis C, extrahepatic manifestations in hepatitis, glomerular injury in hepatitis, acute kidney injury, chronic kidney disease



Corresponding: Vlad Florin Iovanescu, PhD Student, University of Medicine and Pharmacy of Craiova, Romani, Petru Rares St., No.2, Craiova-200349, Romania; e-mail: iovanescu_vlad@yahoo.com


DOI 10.12865/CHSJ.41.03.06 - Download PDF
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