CHSJ

Curr Health Sci J, vol. 41, no. 3, 2015

Formulation and In Vitro Evaluation of Alendronate Sodium/PLGA Microspheres for Applications in Bone Related Disorders

[Original Paper]

A.G. DECA(1), I. BELU(2), O. CROITORU(3), M.V. BUBULICA(3), C.V. MANDA(3), J. NEAMTU(3)


(1)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Doctoral School;
(2)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department II of Pharmacy;
(3)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department I of Pharmacy


Abstract:

Purpose - Bisphosphonates are a group of drugs that can be used in the development of new therapies for bone disorders. Microencapsulation by solvent evaporation is a method that results in microspheres with controlled release of the drug. The purpose of the present study was to include sodium alendronate (AL) in poly (lactic-co-glycolic acid) (PLGA) microspheres with a good encapsulation rate. Furthermore it was intended to obtain a prolonged release of the drug over a period of time. Material and methods - Microspheres were prepared by water/oil/water solvent evaporation method. The microspheres were characterized by FTIR analysis using an Avatar Nicolet spectrophotometer. Both encapsulation ratio and in vitro drug release were assessed by chromatographic analysis. Results - The method chosen for sodium alendronate incorporation resulted in microspheres with a good entrapment efficiency. The in vitro drug release from PLGA/AL microspheres was maintained up to 21 days. This suggests that the microspheres had a sustained releasing tendency. Conclusion - Given the prolonged release, PLGA/AL microspheres may be used in a controlled release system with applications in bone disease treatment.


Keywords: alendronate sodium/PLGA microspheres, bone disorders, formulation, in vitro



Corresponding: Andreea-Gabriela Deca, University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Petru Rares St., No. 2. Craiova, 200349, Romania; e-mail: gabriela_deca@yahoo.com


DOI 10.12865/CHSJ.41.03.09 - Download PDF
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