CHSJ

Curr Health Sci J, vol. 41, no. 4, 2015

Effect of VEGFR, PDGFR and PI3K/mTOR Targeting in Glioblastoma

[Original Paper]

STEFANA OANA PURCARU(1), DANIELA ELISE TACHE(1), FLORENTINA SERBAN(2), ROXANA MIHAELA FOLCUTI(2), ADA MARIA GEORGESCU(2), P.O. STOVICEK(3), MARIA-MIHAELA DANCIULESCU(4), LIGIA GABRIELA TATARANU(5), ANICA DRICU(1)


(1)Biochemistry Dept., Faculty of Medicine, University of Medicine and Pharmacy of Craiova,
(2)PhD Student, Biochemistry dept., Faculty of Medicine, University of Medicine and Pharmacy of Craiova,
(3)Pharmacology dept., Faculty of Medicine, University of Medicine and Pharmacy of Craiova,
(4)Oncology dept., Faculty of Medicine, University of Medicine and Pharmacy of Craiova,
(5)Neurosurgery dept., "Bagdasar-Arseni" Emergency Hospital, Bucharest, Romania


Abstract:

Resistance to targeted therapy is a well known obstacle in cancer therapy. The cross-talk between several growth factor receptors generates redundancy in their intracellular pathways that usually mediates resistance to receptor targeted therapy. Simultaneous inactivation of two or more growth factor receptors has been suggested to prevent the cross-talk between their signaling pathways and to better eliminate malignant cells. Here we found that targeted therapy against these receptors induced moderate cell death in glioblastoma cells. More important, dual PDGFR and VEGFR inactivation induced more pronounceable cell death compared to inactivation of each receptor alone but failed to induce synergistic cell death in glioblastoma. PI3K/mTOR dual targeting has been identified as an efficient therapeutic approach in several malignant diseases, including glioblastoma. Therefore, we also investigated the PI3K/mTOR pathways inhibition effect in glioblastoma cells. Our results showed that inactivation of PI3K/mTOR pathways were more efficient than PDGFR or VEGFR single targeting or their dual inhibition.


Keywords: VEGFR, PDGFR, glioblastoma



Corresponding: Anica Dricu, University of Medicine and Pharmacy of Craiova, 2-4, Petru Rares St., Craiova, Romania. Telephone 0729635161, e-mail: anica.dricu@live.co.uk


DOI 10.12865/CHSJ.41.04.06 - Download PDF
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