CHSJ

Curr Health Sci J, vol. 43, no. 3, 2017

CD44 Immunoexpression in the Progression of Actinic Keratosis and Cutaneous Squamouscarcinoma

[Original Paper]

A. MARINESCU(1), A.E. STEPAN(2), C. MARGARITESCU(2), A.M. MARINESCU(3), R.E. ZAVOI(3), C.E. SIMIONESCU(2)


(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania; 
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
(3)Institute of Legal Medicine, Craiova, Romania


Abstract:

CD44 seems to confer the needed conditions for malignant neoplasms to grow and progress. The present study aims to investigate the role of CD44 expression in pre-invasive and invasive squamous lesions of the skin. We investigated 89 cases of preinvasive and invasive cutaneous lesions, of which 28 corresponded to actinic keratosis (KIN- keratinocyte intraepithelial neoplasia) with varying degrees of severity and 61 cases of squamous cell carcinoma with variable degrees of differentiation. The statistical analysis of CD44 immunoexpression indicated significantly higher values for KIN I and II compared to KIN III, as well as for KIN lesions in comparison with squamous cell carcinomas. Similar results were observed in well differentiated carcinomas compared to moderate and poorly differentiated lesions. These observations suggest that CD44 expression plays a role in the progression of cutaneous squamous neoplasia.


Keywords: CD44, actinic keratosis, squamous cell carcinomas



Corresponding: A.E. Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.43.03.10 - Download PDF
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