CHSJ

Curr Health Sci J, vol. 43, no. 3, 2017

The Role Played by Growth Factors TGF-?1, EGF and FGF7 in the Pathogeny of Oral Pseudoepitheliomatous Hyperplasia

[Original Paper]

R.M. PASCU(1), S. CRAITOIU(2), M.M. CRAITOIU(1), A.M. FLORESCU(1), L. DAGUCI(1), I.C. PETCU(1), C.L. PTRU(3)


(1)Dental Prosthetics Department, University of Medicine and Pharmacy of Craiova, Romania; 
(2)Histology Department, University of Medicine and Pharmacy of Craiova, Romania; 
(3)Obstetrics-Gynecology Department, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Pseudoepitheliomatous hyperplasia is an epithelial proliferation that develops in the dermis or lamina propria. It is a lesion associated to another pathology, which appears as a response to a great variety of infectious, neoplastic, inflammatory or traumatic stimuli. The etiopathogeny of this lesion is not clear yet. Therefore, we performed an immunohistochemical study on a group of 20 cases of pseudoepitheliomatous hyperplasia cases associated with inflammatory and neoplastic conditions, by investigating TGF?1 (Beta growth and transformation factor), EGF (Epidermal growth Factor), and FGF7 (Fibroblast growth factor) expressions during in its development. The TGF-?1 expression was recorded in all the layers of the oral hyperplastic epithelium, going from the basal to the superficial layers, but with a different immunoreactive pattern, according to the region. Our study showed the absence of EGF immunoexpression in the carcinomatous proliferation areas associated to pseudoepitheliomatous hyperplasia and an almost exclusive presence in the hyperplasia lesions associated with inflammatory conditions (in about 30% of the investigated lesions) of a expression varying from poor to moderate for EGF. According to our investigations, we observed the presence of an immunolabeling for FGF7 in 80% of the investigated cases of pseudoepitheliomatous hyperplasia, a maximum of intensity being observed within the cases associated with inflammatory conditions.


Keywords: pseudoepitheliomatous hyperplasia, immunohistochemistry, TGF-?1, FGF7



Corresponding: Pascu Roxana Maria, Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania, e-mail: pascuroxana81@yahoo.com; Pascu Roxana Maria, Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania, e-mail: pascuroxana81@yahoo.com; Pascu Roxana Maria, Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania, e-mail: pascuroxana81@yahoo.com; Pascu Roxana Maria, Department of Prosthetic Dentistry, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania, e-mail: pascuroxana81@yahoo.com


DOI 10.12865/CHSJ.43.03.11 - Download PDF
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