CHSJ

Curr Health Sci J, vol. 43, no. 3, 2017

P21 Immunoexpression in Actinic Keratosis and Cutaneous Carcinomas

[Original Paper]

A. MARINESCU(1), C. MARGARITESCU(2), A.E. STEPAN(2), A.M. MARINESCU(3), C.E. SIMIONESCU(2)


(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania; 
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania; 
(3)Institute of Legal Medicine, Craiova, Romania


Abstract:

Actinic keratosis is a precancerous lesion of the skin with variable rates of transformation into non-melanocytic carcinomas. The present study aims to analyze p21 expression in actinic keratosis and cutaneous squamous carcinomas. P21 expression analysis revealed a positive reaction in 63 (71.4%) of the investigated cases. The immunostaining analysis revealed positivity in 82.1% of the studied actinic keratosis cases and in 43.9% of the investigated carcinomas. High scores of immunoreactions were identified only for the well-differentiated and for the carcinomas in initial stages. Association of p21 expression with pre-invasive or well-differentiated invasive lesions in early stages of tumor progression suggests that p21 may be an early event in squamous carcinogenesis.


Keywords: actinic keratosis, cutaneous squamous carcinomas, p21 immunoexpression



Corresponding: A.E. Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail:astepan76@yahoo.com


DOI 10.12865/CHSJ.43.03.07 - Download PDF
current issue cover Download cover
Download contents

Journal archive