CHSJ

Curr Health Sci J, vol. 43, no. 4, 2017

Formulation and Characterization of Ciprofloxacin loaded PLGA Microspheres for Applications in Orthopedic Infections

[Original Paper]

A.G. MOCANU(1), I. BELU(2), O. CROITORU(3), M.V. CIOCILTEU(3), C.V. MANDA(3), J. NEAMTU(3)


(1)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Doctoral School; 
(2)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department II of Pharmacy;
(3)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department I of Pharmacy


Abstract:

Purpose-Osteomyelitis is a bone infection that appears as a complication after a fracture or orthopedic surgery. Ciprofloxacin is a broad spectrum antibiotic that can be used in local drug delivery systems for the treatment of bone related infections due to its bactericidal activity against both Gram-negative and Gram-positive bacteria. The purpose of the present study was to include ciprofloxacin in poly (lactic-co-glycolic acid) (PLGA) microspheres. Material and methods-Microspheres were prepared by both water/oil/water (w/o/w) solvent evaporation method and solid/oil/water (s/o/w) dispersion solvent evaporation method. The obtained microspheres were characterized by Fourier Transform Infrared Spectroscopy. High performance liquid chromatography method was deployed to determine the encapsulation ratio. Results-The solvent evaporation method chosen for this experiment resulted in microspheres with good entrapment efficiency. Furthermore the microspheres obtained by the s/o/w method displayed better entrapment efficiency. Conclusion-The particles obtained through the s/o/w technique should be further investigated in order to develop a local drug delivery system.


Keywords: ciprofloxacin-PLGA microspheres, solvent evaporation, orthopedic infections, osteomyelitis, local drug delivery



Corresponding: Andreea-Gabriela Mocanu, University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Petru Rares St., No. 2. Craiova, 200349, Romania; e-mail: gabriela_deca@yahoo.com


DOI 10.12865/CHSJ.43.04.03 - Download PDF
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