CHSJ

Curr Health Sci J, vol. 43, no. 4, 2017

P53 Immunoexpression in Laryngeal Squamous Cell Carcinoma

[Original Paper]

L. CERCELARU(1), A.E. STEPAN(1), C. MARGARITESCU(1), A. OSMAN(2), I.C. POPA(1), C.E. SIMIONESCU(1), O. MARGARITESCU(3)


(1)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania; 
(2)Department of Anatomy, University of Medicine and Pharmacy of Craiova, Romania; 
(3)Department of Neurosurgery, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

p53 is a marker described in the premalignant lesions with a high risk of malignant transformation for laryngeal cancer. It is a tumor suppressor gene that during the cancer gains also oncogenic activity. We aimed to study the p53 immunoexpression in 38 cases of laryngeal squamous cell carcinomas and the relation with the clinicopathological aspects. We obtained variable p53 expression regarding the differentiation degree and tumor stage. The higher p53 immunotaining values were observed in high grade and advanced stages lesions. P53 may be useful in identifying aggresive laryngeal squamous carcinomas, a useful aspect for better stratification of patients for therapy.


Keywords: p53, laryngeal squamous cell carcinoma



Corresponding: A.E. Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.43.04.06 - Download PDF
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