CHSJ

Curr Health Sci J, vol. 43, no. 4, 2017

Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line

[Original Paper]

F.M. CRETU(1), B.P. STANOIU(2), C. PISOSCHI(1), A. PREDESCU(3), G. RAU(4)


(1)Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Romania; 
(2)Department of Cell Biology, University of Medicine and Pharmacy of Craiova, Romania; 
(3)Department of Histology, University of Medicine and Pharmacy of Craiova, Romania; 
(4)Department of Organic Chemistry, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® Luminescent Cell Viability Assay. Both compounds tested proved a growth inhibition effect on this cell line in a dose-dependent manner. Our results showed that the compound with procaine effectively reduces breast cancer MDA-MB-231 cells viability and proliferation at higher concentration while that with salicylic acid had an inhibitory effect at lower concentrations and might be tested as an anticancer agent.


Keywords: 1,4-naphthoquinone derivatives, anticancer activity, human breast cancer cells



Corresponding: Catalina Gabriela Pisoschi, Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares St., No 2-4, Craiova, Romania, e-mail: c_pisoschi@yahoo.com


DOI 10.12865/CHSJ.43.04.08 - Download PDF
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