CHSJ

Curr Health Sci J, vol. 43, no. 4, 2017

EGFR Immunoexpression in Laryngeal Squamous Cell Carcinoma

[Original Paper]

L. CERCELARU(1), A.E. STEPAN(1), C. MARGARITESCU(1), A. OSMAN(2), I.C. POPA(1), C. SIMIONESCU(1), O. MARGARITESCU(3)


(1)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Anatomy, University of Medicine and Pharmacy of Craiova, Romania; 
(3)Department of Neurosurgery, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Epidermal growth factor receptor (EGFR) is a tyrosine kinase molecule associated to the initial stages of neoplastic transformation. High expression of EGFR is connected to aggressive tumor behavior and high risk of metastasis and treatment failure. The aim of our study was to analyze the immunohistochemical expression of EGFR in 38 cases of laryngeal squamous cell carcinomas depending on clinicopathological parameters related to prognosis. The EGFR immunoreactions have statistical significant higher values in high grade carcinomas. Although the EGFR values were superior in advanced stages lesions, the aspect was not significant EGFR may be useful in identifying the aggressive laryngeal squamous carcinomas.


Keywords: EGFR, laryngeal squamous cell carcinoma



Corresponding: C. Simionescu, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: csimionescu2004@yahoo.com


DOI 10.12865/CHSJ.43.04.09 - Download PDF
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