CHSJ

Curr Health Sci J, vol. 44, no. 1, 2018

Correlations between CD34 Immunolabelled Blood Vessels and CD34 mRNA Expression in Colorectal Cancer

[Original Paper]

S.C. TOMA(1), C.D. USCATU(2,3), B.S. UNGUREANU(4), C.S.MIREA(1), T. DUMITRESCU(1), E.F. GEORGESCU(1), M. SCHENKER(5), V. SURLIN(1), I. GEORGESCU(1)


(1)Department of Surgery, University of Medicine and Pharmacy of Craiova,
(2)Emergency County Hospital, Pitesti,
(3)Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova,
(4)Research Center in Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova,
(5)Department of Oncology, University of Medicine and Pharmacy of Craiova


Abstract:

Purpose: This study aims to determine the correlation between microvessel density of CD34 immunolabelled blood vessels and CD34 mRNA gene expression in colorectal cancer tissue. Material/Methods: Standard immunohistochemistry and gene expression was perform on samples collected from 76 patients with colorectal cancer in order to determinate the number of CD34 immunolabelled blood vessels and the relative quantity of CD34 mRNA. Results: For the study group, the mean CD34 immunolabelled microvascular density (MVD) was of 307/mm2, and the mean CD34 gene expression value for colon cancer was 2.303. The low p value (<0.001) of the Spearman correlation test showed a significant direct correlation between CD34 MVD and CD34 gene expression for the entire study group. Conclusions: CD34 gene`s expression can be looked at as a prognostic factor in colorectal cancer.


Keywords: colorectal cancer, CD34, vascularization



Corresponding: C.S. Mirea, Department of Surgery, University of Medicine and Pharmacy of Craiova, 1 Mai Avenue, No. 66, Craiova, 200638, Romania, e-mail: cecil.mirea@yahoo.com


DOI 10.12865/CHSJ.44.01.10 - Download PDF
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