CHSJ

Curr Health Sci J, vol. 44, no. 2, 2018

In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex

[Original paper]

C.N. OANCEA(1), A. CIMPEAN(2), R. ION(2), J. NEAMTU(3), A. BITA(4), I.R. SCOREI(5), A.S. NEAMTU(1), O-C. ROGOVEANU(6), S.I. ZAHARIE(7), G. BIRKENMEIER(8)


(1)PhD Student, Doctoral School, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Romania,
(3)Department of Physics, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Pharmacognosy&Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania,
(5)Research Base of Boron Natural Compounds-BioBoron Institute, S.C. Natural Research S.R.L. Craiova, Romania,
(6)Department of Medical Rehabilitation, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania,
(7)Department of Nephrology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania,
(8)Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Germany


Abstract:

In recent years, the role of zinc in biological systems has been a subject of intense research. Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion. The objective of this study, was to assess the toxicity profile of a newly synthesized zinc-boron molecule on cultured cells. Zinc fructoborate, at different levels of concentration, was tested for its impact on the Vero kidney cell line (ATCC® CCL-81™) using the MTT assay. The compound exhibited a low cytotoxic effect on the cell line. Thus, our study demonstrates that the zinc fructoborate could become a promising dietary supplement molecule.


Keywords: zinc fructoborate, in vitro, cytotoxicity, MTT assay, ageing



Corresponding: Andrei Bita, Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, e-mail: andreibita@gmail.com


DOI 10.12865/CHSJ.44.02.03 - Download PDF
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