CHSJ

Curr Health Sci J, vol. 44, no. 2, 2018

In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex

[Original paper]

C.N. OANCEA(1), A. CIMPEAN(2), R. ION(2), J. NEAMTU(3), A. BITA(4), I.R. SCOREI(5), A.S. NEAMTU(1), O.C. ROGOVEANU(6), S.I. ZAHARIE(7), G. BIRKENMEIER(8)


(1)PhD Student, Doctoral School, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Romania;
(3)Department of Physics, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania;
(4)Department of Pharmacognosy&Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania;
(5)Research Base of Boron Natural Compounds-BioBoron Institute, S.C. Natural Research S.R.L. Craiova, Romania;
(6)Department of Medical Rehabilitation, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
(7)Department of Nephrology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
(8)Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Germany


Abstract:

In recent years, the role of zinc in biological systems has been a subject of intense research. Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion. The objective of this study, was to assess the toxicity profile of a newly synthesized zinc-boron molecule on cultured cells. Zinc fructoborate, at different levels of concentration, was tested for its impact on the Vero kidney cell line (ATCC® CCL-81™) using the MTT assay. The compound exhibited a low cytotoxic effect on the cell line. Thus, our study demonstrates that the zinc fructoborate could become a promising dietary supplement molecule.


Keywords: zinc fructoborate, in vitro, cytotoxicity, MTT assay, ageing



Corresponding: Andrei Bita, Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, e-mail: andreibita@gmail.com


DOI 10.12865/CHSJ.44.02.03 - Download PDF
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