CHSJ

Curr Health Sci J, vol. 44, no. 2, 2018

Blood Coagulation Fallowing an Acute Ischemic Stroke

[Original paper]

M.D. SFREDEL(1), E. BURADA(1), B. CATALIN(1,2), V. DINESCU(1), G. TARTEA(1), M. IANCAU(1), E. OSIAC(3)


(1)Department of Physiology, University of Medicine and Pharmacy from Craiova, Romania,
(2)Center of Clinical and Experimental Medicine, University of Medicine and Pharmacy from Craiova, Romania,
(3)Department of Biophysics, University of Medicine and Pharmacy from Craiova, Romania


Abstract:

Objective. Hemostasis is a complex physiological process that stops bleeding at the site of a vascular injury. Although the majority of vascular accidents are ischemic, the role of hypercoagulable state and stroke needs further investigation. Materials and Methods. Fresh whole blood was taken from 61 acute ischemic stroke patients and compared to 18 healthy subjects and investigated with optical coherence tomography imaging after initiating coagulation. We used an OCT1300SS system (Thorlabs) and did 3D scans. We then processed the images with ImageJ. For each image mean, integrated density, skewness and kurtosis of gray values were analyzed. Results. Mean gray value and integrated intensity of sampled data showed an intrinsic difference detected with OCT. This difference was further confirmed by the data distribution analysis. Conclusions. Results suggest, that normal blood coagulation, is not a random reaction while in the case of stroke patients, the relatively symmetrical distribution of gray values brings coagulation closer randomized process.


Keywords: cerebral ischemia, coagulation, optical coherence tomography



Corresponding: Bogdan Catalin, University of Medicine and Pharmacy of Craiova, Str. Petru Rares nr. 4, 200456, Craiova, Dolj, Romania, e-mail: bogdan.catalin@umfcv.ro


DOI 10.12865/CHSJ.44.02.04 - Download PDF
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