CHSJ

Curr Health Sci J, vol. 44, no. 2, 2018

Colorectal Cancer Biomarkers -A New Trend in Early Diagnosis

[Original paper]

S.C. TOMA(1), B.S. UNGUREANU(2), S. PATRASCU(1), V. SURLIN(1), I. GEORGESCU(1)


(1)Ist Clinic of Surgery, Emergency Clinic County Hospital of Craiova, Romania,
(2)Research Center of Gastroenterology and Hepatology of Craiova, Romania


Abstract:

Colorectal cancer (CRC) is one of the most widespread malignancy, posing as a great challenge due to its high incidence and mortality in both genders. Yet, it also stands as one of the most preventable diseases because of its known malignant transformation mostly from tubular adenomas or serrated polyps, therefore offering a strong incentive to the screening programs that are being developed for this disease. Current diagnosis of CRC has surely evolved along with the evolutionary step in gastrointestinal technology of flexible endoscopy. These innovations have promoted colonoscopy as a primary choice for screening programs of colonic lesions, proving to be of great benefit for patient’s well-being. In this review, we present the current status of CRC screening methods from the non-invasive options to the long developed colonoscopic and imaging techniques. We search through PubMed and Medline databases and chose relevant articles on CRC with focus on blood based biomarkers and stool based tests. Additional relevant publications were also according to the reference lists of firstly identified articles.


Keywords: colorectal cancer screening, Blood-Based Biomarkers, Stool Based Tests



Corresponding: Bogdan Silviu Ungureanu, Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy, 66 1 Mai Bvd, 200638 Craiova, Romania, e-mail: bogdan.ungureanu@umfcv.ro


DOI 10.12865/CHSJ.44.02.08 - Download PDF
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