CHSJ

Curr Health Sci J, vol. 44, no. 2, 2018

Histopathological Prognostic Factors for Colic Adenocarcinoma

[Original paper]

A-M. AL KHATIB(1), A.E. STEPAN(2), C. MARGARITESCU(2), B.C. ANDREIANA(2), M-M. FLORESCU(2), C.E. SIMIONESCU(2), R.N. CIUREA(2)


(1)PhD student, Department of Pathology, University of Medicine and Pharmacy of Craiova,
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova


Abstract:

The majority of colorectal carcinomas are adenocarcinomas derived from the colic mucosae cell, more frequently moderately differentiated. The purpose of this study was to determine de incidence of CRC and the relationship between histopathological risk factors in patients with colic adenocarcinomas. The study included 144 cases of CRC diagnosed within the Pathology Laboratory of the Clinical County Hospital of Craiova in the year 2017.The biological material consisted in samples from colectomies and hemicolectomies provided from patients admitted within the surgical clinics of the same hospital, then fixed with 10% buffered formalin and afterwards processed using the classic histopathological technique of paraffin inclusion and staining with hematoxylin and eosin. We observed certain histopathological parameters such as: pattern, grading, stage, vascular invasion and neural invasion. The mean age of diagnostic was 68,6±11,2, and it was predominantly male patients (64.6%). Most cases presented with mucinous pattern (31.9%) and cribriform comedocarcinoma type (29.9%). The majority were classified as stage III B (34%), being moderately differentiated (64,6%) and associated with vascular invasion (47,2%) and perineural invasion (25,7%). Statistical analysis indicated significant relationships between tumor stage and differentiation grade (p<0,01, X2test), as well as between tumor stage and vascular invasion (p<0.05, X2test), without including perineural invasion (p<0.05, X2test).


Keywords: colic adenocarcinoma, tumoral stage, grading, prognostic



Corresponding: Claudiu Margaritescu, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66, 1 May Avenue, 200628 Craiova, Romania, e-mail: c_margaritescu2000@yahoo.com


DOI 10.12865/CHSJ.44.02.09 - Download PDF
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