Curr Health Sci J, vol. 44, no. 3, 2018

Histopathological Prognostic Factors in Clear Cell Renal Cell Carcinoma

[Original Paper]

B.C. ANDREIANA (1), A.E. STEPAN (2), C. MARGARITESCU (2), A.M. AL KHATIB (1), M.M. FLORESCU (2), R.N. CIUREA (2), C.E. SIMIONESCU (2)


(1)PhD student, Department of Morphopathology, University of Medicine and Pharmacy of Craiova,
(2)Department of Morphopathology, University of Medicine and Pharmacy of Craiova


Abstract:

Clear cell renal cell carcinoma (CCRCC) are the most frequent type of renal cell carcinoma. Fuhrman grade and tumor stage are prognostic factors with great importance in survival rate. This study was performed on 75 cases of CCRCC diagnosed by the Anatomical Pathology Laboratory of the County Clinical Emergency Hospital of Craiova between 2014 and 2017. The biological material was represented by pieces of nephrectomy. The cases were analyzed on two criteria: epidemiology (age, sex) and histopathology (Fuhrman grade, tumor stage, architectural pattern, sarcomatoid transformation, and necrosis). Statistical analysis was done using Chi Square tests in IBM SPSS software. Average diagnosis age of CCRCC was 58.8±10.2 years, predominantly in male patients (66.7%). Tumor sizes were between 2 and 14cm, with an average of 6.7±2.9cm. Most cases were determined to be tumor stage III (60%) and Fuhrman grade 2 (56%), followed, in order of frequency, by tumor stages I and II (28% and 10.7%) and Fuh


Keywords:
Clear cell renal cell carcinoma, Fuhrman grade, tumor stage, architectural pattern



Corresponding:
Claudiu Margaritescu, MD, PhD, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66, 1 May Avenue, 200628 Craiova, Romania; e-mail: c_margaritescu2000@yahoo.com


DOI 10.12865/CHSJ.44.03.01 - Download PDF