Curr Health Sci J, vol. 44, no. 3, 2018

Q-T Interval Prolongation in Patients with Liver Cirrhosis

[Original Paper]

E. TIERANU(1), I. DONOIU(1), O. ISTRATOAIE(1), A.E. GAMAN(2), L.M. TIERANU(3), D.I. GHEONEA(4), T. CIUREA(4)


(1)Department of Cardiology, University of Medicine and Pharmacy, Craiova, Romania,
(2)Department of Bacteriology-Virology-Parasitology, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Internal Medicine, University of Medicine and Pharmacy, Craiova, Romania


Abstract:

Liver cirrhosis (LC) is the end stage of chronic liver disease characterized by the appearance of extensive fibrosis and regeneration nodes associated with hepatocyte necrosis in liver but also by the reshuffling of hepatic architecture. The triad consisting of hepatic parenchymal necrosis, regeneration and scarring is always present regardless of the type of clinical manifestation. The Child-Pugh-Turcotte classification dates back more than 30 years and has been widely used in diagnosing and assessing the severity of liver cirrhosis. This is preferred due to a low degree of complexity and a good predictive value. Prolongation of the QT interval on the electrocardiogram is common, with a prevalence exceeding 60% in patients with advanced stage of cirrhosis. In these cases, beta blockers and antiarrhythmics should be avoided or used with caution and with close QT interval monitoring. Changes in heart rate and Q-T interval are new entities in cirrhosis complications. A prolonged Q-T inte


Keywords:
Liver cirrhosis, Q-T interval, beta-blockers, Child-Pugh Classification



Corresponding:
Ionu Donoiu, Department of Cardiology, Craiova University of Medicine and Pharmacy, 2 Petru Rare Street, 200349 Craiova, Romania, e-mail: ionut.donoiu@umfcv.ro


DOI 10.12865/CHSJ.44.03.11 - Download PDF