Curr Health Sci J, vol. 44, no. 3, 2018

Histopathological Aspects of the Myocardium in Dilated Cardiomyopathy

[Original Paper]

R. MITRUT(1), A.E. STEPAN(2), D. PIRICI(3)


(1)PhD student, Department of Pathology, University of Medicine and Pharmacy of Craiova,
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova,
(3)Department of Research Methodology, University of Medicine and Pharmacy of Craiova


Abstract:

Dilated cardiomyopathy is the most common form of cardiac muscle disease, accounting for approximately 60% of all cardiomyopathies. We proposed to identify histopathological changes of the myocardium in dilative cardiomyopathy. This study comprised a total of 19 cases, represented by myocardial fragments from deceased patients with diagnosis of dilated cardiomyopathy. Histopathological analysis allowed changes to be observed for both myocytes and myocardial interstitial components. We have found a combination of hypertrophic, atrophic and normal myocardocytes, or associated with the presence of hydropic changes. We rarely identified the aspect of myocytosis, cytoplasmic accumulation of lipofuscin pigment or mucinous material, and variable nuclear pleomorphism. At the interstitial level we noticed changes in fibrosis, lipomatosis and rarely the presence of inflammatory infiltrate. Histopathological characteristics of the myocardium in dilated cardiomyopathy are numerous but nonspecific,


Keywords:
Dilated myocardiopathy, histopathology



Corresponding:
Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.44.03.07 - Download PDF