CHSJ

Curr Health Sci J, vol. 44, no. 4, 2018

Evaluation of Gastric Carcinomas Histological Patterns in Relation to Tumors Aggressiveness Parameters

[Original paper]

MARIA DOBRIOIU(1), ALEX EMILIAN STEPAN(2), CRISTIN-CONSTANTIN VERE(3), CRISTIANA EUGENIA SIMIONESCU(2)


(1)PhD, University of Medicine and Pharmacy of Craiova
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova
(3)Department of Gastroenterology, University of Medicine and Pharmacy of Craiova


Abstract:

Gastric carcinomas are frequent tumors with variable growth patterns that may interfere with the evaluation of histopathological prognostic parameters of the lesions. In this study we analyzed the incidence and statistical relation of histological growth patterns depending on the prognostic parameters of gastric carcinomas for 95 cases. Pure forms were present in 82.2% of cases, from which more frequent subtypes were low grade tubular carcinomas and poorly cohesive with signet-ring cells carcinomas. Mixed forms were present in 17.8% of cases, with the highest incidence of tumors containing well differentiated tubular carcinoma and poorly differentiated papillary carcinoma areas. Analysis of the identified types and subtypes in relation to the histological prognostic parameters indicated significant differences regarding the tumor stage, the mixed subtypes being more frequent in advanced stages. Although mixed subtypes were more commonly associated with vascular and perineural invasion, the aspects were statistically insignificant. Together with tumor stage, the lymphovascular and/or perineural invasion should be taken into consideration as prognostic indicators in the postoperative management of gastric cancer.


Keywords: Gastric carcinoma, histological pattern, prognostic parameters



Corresponding: Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.44.04.03 - Download PDF
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