CHSJ

Curr Health Sci J, vol. 45, no. 1, 2019

The Link Between Bone Osteocalcin and Energy Metabolism in a Group of Postmenopausal Women

[Original paper]

N. DUMITRU(1,2), M. CARSOTE(1,2), A. COCOLOS(1,2), E. PETROVA(1,2), M. OLARU(1), C. DUMITRACHE(2), A. GHEMIGIAN(1,2)


(1)C.I. Parhon National Institute of Endocrinology, Bucharest, Romania,
(2)”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania


Abstract:

There is a dual relationship between bone and tissues involved in energy metabolism (fat tissue and beta-pancreatic cells). Thus, bone remodeling is an energy consuming process, but osteocalcin, the main non-collagenic protein, synthesized by osteoblas during bone formation exerts a number of biological effects on beta-pancreatic and adipose cells. With this data, we wanted to see if the presence of a chronic metabolic disorder such as type 2 diabetes mellitus (T2DM) influence this complex dual relationship. For this, we conducted a cross-sectional study to evaluate the relation between osteocalcin and energetic metabolism in a group of 146 postmenopausal womens with and without T2DM at CI Parhon National Institute of Endocrinology, Bucharest. Clinical, metabolic and hormonal parameters were evaluated. For statistical analysis we used Student t-test and the Spearman correlation (statistical significance: p <0.05). Results: 63 patients with T2DM (63.88±8.56 years) and 83 women in the control group (60.21±8.77 years) were included. Diabetic women showed a lower level of serum total osteocalcin (p<0.05) HDL-cholesterol (p=0.02), and 25-hydroxyvitamin D (25(OH)D). The body mass index (BMI), glycemic metabolism parameters and triglyceride levels (p<0.05) were higher in this group. We found correlations between osteocalcin and metabolic elements: negative with BMI (r=-0.329, p<0.05), glycated hemoglobin (HbA1c) (r=-0.398, p<0.05), and serum triglycerides (r=-0.329, p<0.05) respectively positive with HDL-cholesterol (r=0.279, p=0.001) for the entire group of patients. Conclusions: Our study indicated the presence of significant correlations between serum osteocalcin and glycemic and lipid metabolism parameters, independent of the presence of diabetes.


Keywords: Bone turnover, osteoblast, osteocalcin, energy metabolism, insulin



Corresponding: Nicoleta Dumitru, Aviatorilor Ave 34-38, Bucharest, sector 1, postal code 011684, Romania, e-mail: nicoleta3fan@gmail.com


DOI 10.12865/CHSJ.45.01.06 - Download PDF
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