Curr Health Sci J, vol. 45, no. 2, 2019

A Statistical Analysis of Risk Groups in Colorectal Cancer Patients

[Original Paper]

R.M. FLORESCU-TENEA(1), A.M. KAMAL(2), P. MITRUT(3,4), R. MITRUT(1), D.S. ILIE(1), A.C. NICOLAESCU(5), L. MOGOANTA(6)


(1)PhD Student, Department of Histology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Gastroenterology, “Renaşterea” Medical Center, Craiova, Romania,
(4)Department of Semiology, University of Medicine and Pharmacy of Craiova, Romania,
(5)PhD Student, Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania,
(6)Department of Histology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Colorectal cancer (CRC) is considered a major global health concern due to an increasing number of new cases and cancer-related deaths each year, strong link to dietary habits prevalent in middle and high-income countries and limited therapeutic options especially in locally-advanced and metastatic settings. To counter this growing problem, the scientific community has strived to underpin the major molecular mechanisms behind the aggressive phenotype displayed by CRC and also develop new agents to selectively target and inhibit these core drivers. This evolution has allowed the separation of patients according to different risk groups in concordance with epidemiological parameters alongside novel biomarkers such as gene alterations, protein overexpression and aberrant signaling pathways. In this study we included 20 patients who underwent colonoscopy and were later received histopathologic confirmation of CRC. The statistical anamnestic data obtained from the patients (age, gender, home distribution, signs and symptoms) was corroborated with the results obtained from the histopathologic and immunohistochemical analysis of the samples obtained via colonoscopy. The average age was 63.8 years, the male: female ratio was 2.33 and the origin of 2/3 of the patients was urban and the most encountered symptoms were transit disorders (75%). In terms of colonoscopy results, the majority of tumors were found on the rectum (85%), 90% of tumors were adenocarcinomas, having a vegetant aspect in 60% of the cases and a moderate degree of differentiation in 50% of situations.


Keywords:
Colorectal cancer, incidence, angiogenesis, immunohistochemistry, colonoscopy



Corresponding:
Adina Maria Kamal, Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Dolj County, Romania, e-mail: adinaka@gmail.com


DOI 10.12865/CHSJ.45.02.08 - Download PDF