Curr Health Sci J, vol. 45, no. 2, 2019

Snail and E-Cadherin Immunoexpression in Clear Cell Renal Cell Carcinoma

[Original Paper]

B.C. ANDREIANA(1), A.E. STEPAN(2), C. MARGARITESCU(2), O. TAISESCU(3), A. OSMAN(3), C.E. SIMIONESCU(2)


(1)PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Anatomy, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Renal cell clear cell carcinomas (ccRCC) represent 75% of the malignant renal neoplasias. A critical molecular characteristic in the epithelial-mesenchymal transition (EMT) is the loss of E-cadherin expression, as well as the epithelial-mesenchymal transcription factors, one of the most important of which is Snail. In the current study, we analyzed the immunoexpression of the two markers in 46 cases of clear cell renal cell carcinomas, with reference to the most important prognosis histopathological factors. Our results indicated significant associations between the overexpression of Snail, under expression of E-cadherin and high Fuhrman grade. E-cadherin immunoexpression was high in incipient tumoral stages, and Snail was overexpressed in advanced tumoral stages of ccRCC. Our study supports the importance of this antibody panel in the prognosis of ccRCC.


Keywords:
Clear cell renal cell carcinoma, Snail, E-cadherin



Corresponding:
Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.45.02.09 - Download PDF