Curr Health Sci J, vol. 45, no. 3, 2019

Effects of Platelet Rich Fibrin on Full Thickness Skin Grafts in the Rat Model-Planimetry Results

[Original Paper]

O. NICA (1,2), D.G. POPA (2), A.F. GRECU (1,3), E.M. CIUCA (4), M.E. CIUREA (2)

1) PhD Student, Doctoral School, University of Medicine and Pharmacy of Craiova, Romania 2) Department of Plastic Surgery and Reconstructive Microsurgery, University of Medicine and Pharmacy of Craiova, Romania 3) Department of Orthopedics and Traumatology, Emergency County Hospital, Craiova, Romania 4) Department of Oral and Maxillofacial Surgery, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Platelets play a crucial role in wound healing as they are reservoirs of growth factors and cytokines which play a fundamental role in homeostasis and tissue remodeling.Recently, fields such as dermatology and plastic and reconstructive surgery have become interested in the tissue regenerative properties of these compounds, especially since it promotes wound healing, improves scar outcomes and has rejuvenating effects on the skin and other tissues.We evaluated the effects ofPlatelet Rich Fibrin(PRF) in full thickness skin graft healing. Our study included 40 male Wistar rats. Skin grafts were assessed macroscopically using planimetry.The full thickness skin grafts in the test group, displayed a lower necrosis rate compared to the control group. Our study displays the potential benefits of using Platelet Rich compounds to facilitate wound healing and integration of full thickness skin grafts.


Keywords:
Full thickness skin graft, platelet rich fibrin, dermal necrosis, planimetry



Corresponding:
Alexandru Florian Grecu, PhD Student, Doctoral School, University of Medicine and Pharmacy of Craiova, Department of Orthopedics and Traumatology, Emergency County Hospital, Craiova, Romania, e-mail: alexandrugrecu@yahoo.com


DOI 10.12865/CHSJ.45.03.05 - Download PDF