CHSJ

Curr Health Sci J, vol. 46, no. 1, 2020

Adenoid Cystic Carcinoma of Salivary Gland: A Ten-Year Single Institute Experience

[Original paper]

I.C. BELULESCU(1), C. MARGARITESCU(1), C.I. DUMITRESCU(2), L. DAGUCI(3), C. MUNTEANU(4), O.C. MARGARITESCU(5)


(1)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Clinical Pharmacology, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Prosthodontics, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania,
(5)Department of Neurosurgery, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Adenoid cystic carcinoma is a rare tumor, accounting for about 7.5% of all salivary gland neoplasms. More frequent developing in minor salivary gland, this is a slow-growing tumor with a long-lasting natural evolution, quite aggressive locally, but which has a tendency toward local recurrence and even for distant metastasis. We conducted a retrospective study limited to a period of 10 years in a single medical institution to investigate the morphoclinical profile of this tumor. Thus, we have established that about 60% of the tumors developed in men, with near 40% of the cases in patients in the sixth decade and, most common, the pathology affected the parotid and minor salivary glands from the hard palate mucosa. Histopathologically, prevailed the solid variant, with 72% cases presenting perineural invasion, and 41% cases showing positive surgical resection margins. Most cases had a long-standing asymptomatic evolution, so that at the time of diagnosis, more than two thirds of the patients were at least in stage II-pTNM, and in one-fifth of the cases histopathology showed lymph nodes disseminations.


Keywords: Adenoid cystic carcinoma, salivary gland, epidemiology, histopathology.



Corresponding: Claudiu Margaritescu, Department of Pathology, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, 66, 1 May Avenue, 200628 Craiova, Romania, e-mail: c_margaritescu2000@yahoo.com


DOI 10.12865/CHSJ.46.01.08 - Download PDF
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