Curr Health Sci J, vol. 46, no. 2, 2020

Classical Therapies Versus Combined Therapies in Diabetic Neuropathy

[Original paper]


(1)Physiology Department, University of Medicine and Pharmacy of Craiova,
(2)Neurology Department, University of Medicine and Pharmacy of Craiova


The aim of our study was to evaluate the classical therapies represented by adequate glycemic control and lifestyle changes versus classical therapies combined with new antioxidant therapies in patients with diabetic neuropathy. We conducted an observational, prospective study, between October 2017 and December 2019, which included a number of 188 patients suffering from diabetic neuropathy. In order to evaluate the response to the therapeutic protocol, we used the MNSI (Michigan neuropathy screening instrument). Responder group was defined as a decrease in MNSI (<7) from baseline to one year. According to this 34.04% (n=64) of patients were responders to classical therapy while a higher number of patients responded to combined therapy (n=73, representing 38.83%). In the group of responders, the subgroups that predicted the prevention of MNSI increase (decrease in the impact of diabetic neuropathy) in the group treated with combined therapy compared to classical therapy, related to clinicopathological features, after one year included: gender female (p=0.0415), body mass index <30kg/m2 (p=0.0335), absence of cardiovascular disease (p=0.0006) and absence of dyslipidemia (p=0.0288). In conclusion, we demonstrated an increased response to combined therapy after one year of treatment. Thus, combined therapy is an alternative for reducing side effects and for increasing efficiency.

Antioxidant therapy, glycemic control, lifestyle changes, diabetic neuropathy

Andreea Rotaru, University of Medicine and Pharmacy of Craiova, Physiology Department, 2 Petru Rares Str., 200349 Craiova, Romania, e-mail:

DOI 10.12865/CHSJ.46.02.04 - Download PDF