CHSJ

Curr Health Sci J, vol. 46, no. 3, 2020

Facing the Unseen - Metabolic Syndrome in Psoriatic Arthritis

[Original Paper]

B.A. CHISALAU(1), C.D. PARVANESCU(1), A.L. BARBULESCU(2), S.C. FIRULESCU(1), S.C. DINESCU(3), R.M. DUMITRASCU(1), R.E. SANDU(4), P.L. CIUREA(3), F.A. VREJU(3)


(1)PhD student, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Rheumatology, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Psoriatic arthritis (PsA) is a heterogeneous multifaceted inflammatory artropathy, associated or not with psoriasis, part of the spondyloarthropaties group. Beyond articular and skin manifestations, patients with psoriatic disease are prone to associated comorbidities, including cardiovascular disease (CVD), obesity and metabolic syndrome, diabetes, or fatty liver disease; in order to improve the prognosis and the quality of life for these patients, it is mandatory to prevent, identify and properly manage any of the comorbidities. We aimed to assess the presence of traditional CV risk factors and MetS in a group of PsA patients, compared to controls and their possible inter-relation. We performed an observational study on 41 consecutive patients diagnosed with PsA based on CASPAR established criteria. Our subjects met the criteria of MetS in a percentage of 43.90% of the cases and AHT, frequently reported in higher percentages for PsA or psoriasis patients, compared to general population was also revealed in significant percentages by our data. Regarding dyslipidemia, it is confirmed and validated by several studies that patients diagnosed with PsA or psoriasis associate an altered lipid metabolism and our study noticed data accordingly. As PsA is a condition characterized by chronic inflammation, a non-traditional CV risk factor, each patient should benefit from a periodic close evaluation in order to approach a compete and early therapeutic intervention and reduce further CV morbidity and mortality rates.


Keywords: Psoriatic arthritis, metabolic syndrome, cardio-vascular risk factors.



Corresponding: Andreea Lili Barbulescu, Department of Pharmacology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Dolj County, e-mail: anbarbulescu@gmail.com


DOI 10.12865/CHSJ.46.03.09 - Download PDF
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