CHSJ

Curr Health Sci J, vol. 46, no. 4, 2020

Claudin-4 Immunoexpression in Urothelial Carcinomas

[Original Paper]

A.S. SANDULESCU(1), A.E. STEPAN(2), C. MARGARITESCU(2), A.M. BADIU(2), M. MATEI(3), C.E. SIMIONESCU(2)


(1)PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
(3)Department of Histology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

The involvement of claudins in urothelial carcinogenesis is controversial. In this study, we analyzed Claudin-4 immunoexpression in 50 cases of bladder urothelial carcinomas depending on the main prognostic parameters of the lesions represented by the tumor grade and tumor extension. Claudin-4 immunoexpression scores were significantly higher in high-grade urothelial carcinomas and in tumors with invasion in muscularis propria. The results obtained indicate the involvement of Claudin-4 in the progression of urothelial bladder carcinomas.


Keywords: Bladder carcinoma, Claudin-4, tumor grade.



Corresponding: Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.46.04.08 - Download PDF
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