CHSJ

Curr Health Sci J, vol. 46, no. 4, 2020

Claudin-4 Immunoexpression in Urothelial Carcinomas

[Original Paper]

A.S. SANDULESCU(1), A.E. STEPAN(2), C. MARGARITESCU(2), A.M. BADIU(2), M. MATEI(3), C.E. SIMIONESCU(2)


(1)PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Histology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

The involvement of claudins in urothelial carcinogenesis is controversial. In this study, we analyzed Claudin-4 immunoexpression in 50 cases of bladder urothelial carcinomas depending on the main prognostic parameters of the lesions represented by the tumor grade and tumor extension. Claudin-4 immunoexpression scores were significantly higher in high-grade urothelial carcinomas and in tumors with invasion in muscularis propria. The results obtained indicate the involvement of Claudin-4 in the progression of urothelial bladder carcinomas.


Keywords: Bladder carcinoma, Claudin-4, tumor grade.



Corresponding: Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.46.04.08 - Download PDF
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