CHSJ

Curr Health Sci J, vol. 47, no. 1, 2021

Risk Factors and Genetic Predisposition in Colorectal Cancer: A Study on Young and Old Adults

[Original Paper]

C.B. Petre-Mandache(1), D.N. Margaritescu(2), R. Mitrut(3), A.M. Kamal(4), V. Padureanu(4), M.G. Cucu(5), P. Mitrut(4)


(1)Medical Genetics Department, Emergency County Hospital Craiova, Romania,
(2)Surgery Department, University of Medicine and Pharmacy of Craiova, Romania,
(3)Cardiology Department, University of Medicine and Pharmacy of Craiova, Romania, Emergency University Hospital Bucharest, Romania,
(4)Internal Medicine Department, University of Medicine and Pharmacy of Craiova, Romania,
(5)Medical Genetics Department, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

According to GLOBOCAN 2018 data Colorectal cancer (CRC) represents the third most commonly diagnosed cancer in the world and has the second-highest mortality rate. The incidence of CRC has been rising worldwide, the majority of cases being in developing countries mostly due to the adoption of an unhealthy lifestyle. The main driving factors behind CRC are a sedentary lifestyle, obesity, red meat consumption, alcohol, and tobacco; however, early detection screenings and standardized treatment options have reduced CRC mortality. Better family history and genetic testing can help those with a hereditary predisposition in taking preventative measures.


Keywords: Colorectal cancer, Risk factors, Epidemiology, Inherited Colorectal Cancer.



Corresponding: Carmen-Bianca Petre-Mandache, Department of Medical Genetics, SCJU Craiova, 1 Tabaci Street, 200642, Craiova, Dolj County, Romania, e-mail: aknaib86@gmail.com


DOI 10.12865/CHSJ.47.01.13 - Download PDF
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