CHSJ

Curr Health Sci J, vol. 47, no. 1, 2021

VEGF Immunoexpression in Prostate Adenocarcinoma

[Original Paper]

A. Panu(1), C.E. Simionescu(2), P.O. Dragoescu(3), A.E. Stepan(2)


(1)PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Urology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions.


Keywords: VEGF, Gleason score, prostate adenocarcinoma.



Corresponding: Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.47.01.14 - Download PDF
current issue cover Download cover
Download contents

Journal archive