CHSJ

Curr Health Sci J, vol. 47, no. 1, 2021

VEGF Immunoexpression in Prostate Adenocarcinoma

[Original Paper]

A. PANUS(1), C.E. SIMIONESCU(2), P.O. DRAGOESCU(3), A.E. STEPAN(2)


(1)PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
(3)Department of Urology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions.


Keywords: VEGF, Gleason score, prostate adenocarcinoma.



Corresponding: Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.47.01.14 - Download PDF
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