Curr Health Sci J, vol. 47, no. 1, 2021

The Profile of the Patients with Double Infection HIV and TB in South West of Romania

[Original Paper]

C. Stoica [Calarasu](1), A.M. Popa [Miulescu](1,2), A.A. Turcu(3,4), F.M. Nitu(4)

(1)University of Medicine and Pharmacy of Craiova,
(2)Department of Pulmonology Clinical Pulmonary Leamna Hospital,
(3)Department of Dental Prevention, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, Romania,
(4)“Victor Babeş” Clinical Hospital of Infectious Diseases and Pneumophtisiology, Craiova


Background: Co-infection with human immunodeficiency virus (HIV) / tuberculosis (TB) raises important diagnostic and treatment problems as the lung is one of the target organs for HIV. Studies have shown that an HIV patient is 5-15 times more likely to switch from Koch's bacillus-infected status to active tuberculosis. Material and method: Retrospective study on 207 patients with HIV/TB coinfection in the Oltenia area registered in the Regional Center for Monitoring and Evaluation of HIV/AIDS infection in Craiova to define the profile of patients with double TB-HIV infection in southern Romania for cases registered between 2005-2015. Results: 53.14% of patients were females. Most cases were from rural areas (56.10%) Half of them are born between 1988 and 1990 but only 5% graduated university. 66.18% don’t have a job and are supported by state with a monthly minimum income. 29.4% are smokers. More than 60% of cases had pulmonary TB and other 25% had concomitant pulmonary and extrapulmonary TB. TB and HIV have been diagnosed almost at the same time in 25% of cases. At the time of TB diagnosis 75% of patients had CD4+lymphocytes count <200cel/ml. We also noticed the absence of prophylaxis for TB in patients infected with HIV (PIH) and high incidence of hepatitis B (30.43%). Conclusions: Clinical expression, radiological and bacteriological aspects are often atypical in HIV/TB coinfected patients. The lack of TB prophylaxis and TB endemicity in the studied area may justify the large number of TB cases in HIV-infected patients.

Pulmonary tuberculosis, HIV, co-infection, immunosuppression.

Cristina Stoica (Calarau), Ph D Student, University of Medicine and Pharmacy of Craiova, 2 Petru Rares St., Craiova, Romania, e-mail:

DOI 10.12865/CHSJ.47.01.17 - Download PDF