Curr Health Sci J, vol. 47, no. 2, 2021

The Effect of Switching to Long Acting Injection (LAI) Antipsychotic Therapy on Patients with Schizophrenia

[Original Paper]

Livia Mihaela Strunoiu(1), Mircea Mihai Duescu(2), Cristian Marian Strunoiu(3), Dragos Ovidiu Alexandru(4), Mihail Cristian Pirlog(5), Andrei Adrian Tica(6)


(1)Doctoral School, University of Medicine and Pharmacy of Craiova, Romania, Outpatient Psychiatric Unit, Municipal Hospital “Filantropia” Craiova, Romania,
(2)Doctoral School, University of Medicine and Pharmacy of Craiova, Romania, Chronic Hospital of Psychiatry, Dumbrăveni, Romania,
(3)Department of Psychiatry, Slatina Emergency County Hospital, Romania,
(4)Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania,
(5)Department of Sociology, University of Medicine and Pharmacy of Craiova, Romania,
(6)Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Material and method: We analyzed 362 patients with schizophrenia admitted during 2016 in an acute psychiatric ward and in a chronic psychiatric ward, diagnosed with paranoid or other schizophrenia, according to DSM-IV-TR, which, after remission of the symptoms of the acute episode, they benefited from antipsychotic therapy only in oral formulation. For some of these patients we instituted maintenance therapy with depot formulas. Patients were followed for up to two years. Results: Comparing the level of adherence to therapy, we found a statistically significant improvement, from 42.96% to 76.30%. Although we estimate that adherence to LAI therapy is over 90%, almost a quarter of patients have given up this type of treatment at some point due to side effects. Carrying out the comparative analysis of the number of hospitalizations per year, from the past and from the follow-up period, as well as of the scores registered at the scales used (PANSS, CGI, GAS, WHOQOL), in dynamics, we demonstrated the appearance of statistically significant changes. Conclusions: the administration of antipsychotic therapy through LAI-type depot formulas can improve the therapeutic adherence of the patient with schizophrenia, thus improving the evolution of the disease and the quality of life.


Keywords:
Schizophrenia, antipsychotic therapy, LAI, PANSS, WHOQOL



Corresponding:
Dragos Ovidiu Alexandru, Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, 2, Petru Rare St, Craiova 200349, e-mail: dragosado@yahoo.com


DOI 10.12865/CHSJ.47.02.14 - Download PDF