Curr Health Sci J, vol. 47, no. 2, 2021

Study of Cognitive Disfunctions in Thyroid Pathology

[Original Paper]

Oana-Maria Nicola (Marioara)(1), Mihaela Popescu(2), Cristina-Nicoleta Vladoianu(3), Valentin Carlig(4), Mara Carsote(5), Alice Elena Ghenea(6)


(1)Doctoral School, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova,
(3)Resident Physician, Endocrinology, Filantropia Clinical Hospital Craiova,
(4)Department of Pharmacology, University of Medicine and Pharmacy of Craiova,
(5)University of Medicine and Pharmacy “Carol Davila”, Bucharest, Faculty of Medicine, Departament of Endocrinology, National Institute of Endocrinology "C.I. Parhon",
(6)Departament of Bacteriology-Virology-Parasitology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Clinical Emergency County Hospital, Craiova


Abstract:

Thyroid pathology is characterized by abnormal values of thyroid hormones that can affect the brain and can lead to cognitive impairment (attention, memory, mood), depression and anxiety. The aim of the study is to evaluate the association between the cognitive disorders and thyroid disease and the link between thyroid hormone levels FT4 and TSH in depression and anxiety. We included 130 individuals from Endocrinology Clinic of Craiova, over a period of 6 years (2014-2020), none of whom was taking thyroid medication and antidepressants. The most important symptom found in thyroid pathology is depression, which occurs in those with long-lasting illness. We obtained that 45.38% of the cases were diagnosed with depression and 46.92% with anxiety. Depressive symptoms were assessed with Hamilton scale and anxiety symptoms with the Beck scale. Regarding the impaired cognitive function, we found it in 34.7% of cases of hypothyroidism (loss of memory / lack of concentration) and for the cases with hyperthyroidism, we found changes in 51,42%.


Keywords:
Hyperthyroidism, hypothyroidism , depression, anxiety, memory



Corresponding:
Mihaela Popescu, Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Dolj County, Romania, e-mail: mihaela.n.popescu99@gmail.com


DOI 10.12865/CHSJ.47.02.16 - Download PDF