Curr Health Sci J, vol. 47, no. 2, 2021

Evaluation of the Relationship among Pulmonary Artery Pressure with Serum Ferritin Level and CMR T 2* in Thalassemia Major

[Original Paper]

Fatemeh Ostad-Hosini(1), Mohammad Reza Safaei Qomi(1), Aziz Eghbali(2), Vahid Falahati(3), Sarvenaz Mehrabi(1), Yazdan Ghandi(3)

(1)School of Medicine, Arak University of Medical Sciences, Arak, Iran,
(2)Pediatric Oncology, Iran University of Medical Sciences, Tehran, Iran,
(3)Pediatric Oncology, Amir-Kabir Hospital, Arak University of Medical Sciences, Arak, Iran


Background: Pulmonary hypertension is one of the most common cardiac complications among patients with β-thalassemia major (β-TM). The aim of this study is to investigate the correlation of pulmonary artery pressure (PAP), serum ferritin level, and cardiac T2* MRI in patients with β-TM. Method: This cross-sectional study was performed on 50 patients older than 7 years old. Echocardiography, electrocardiography, and cardiac T2* MRI were performed on all patients and their serum ferritin levels were measured. Based on the echocardiographic the patients were divided into two groups of PAP>30 and <30 mmHg. Results: 40% had PAP higher than 30 mmHg, 32% had abnormal T2* MRI, and 36% had serum ferritin levels higher than 1500ng/dl. there were significant negative correlations between CMRI *T2 and PAP (-0.36) and the P-pulmonary (-0.29). the serum ferritin level was positively correlated with PAP (0.44) and the P pulmonary in ECG (0.30). in the patients with PAP>30, the means of age, serum ferritin level, and P-pulmonary were significantly higher than patients with PAP<30 (P=0.001). In the patients with PAP>30mmHg, CMRI *T2 had higher accuracy (80%), sensitivity (65%), and specificity (90%) compared to the measurement of serum ferritin levels. Conclusion: The PAP was positively correlated with serum ferritin levels and negatively with T2MRI. The accuracy of 80% for T2MRI as a method to diagnose or even anticipate PH among patients with TM suggested that this method is a useful and accurate method of PH diagnosis and can be used as an alternative among clinicians.

Β-Thalassemia Major, Cardiac T2* MRI, Pulmonary Artery Pressure, Serum Ferritin Levels

Yazdan Ghandi, Pediatric Cardiologist, Amir Kabir Hospital, Arak University of Medical Sciences, Arak, Iran, ORCID ID: 0000-0002-8825-7163, Zip code: 3817996647, e-mail:

DOI 10.12865/CHSJ.47.02.06 - Download PDF