CHSJ

Curr Health Sci J, vol. 47, no. 2, 2021

Evaluation of the Relationship among Pulmonary Artery Pressure with Serum Ferritin Level and CMR T 2* in Thalassemia Major

[Original Paper]

F. OSTAD-HOSINI(1), M.R. SAFAEI QOMI(1), A. EGHBALI(2), V. FALAHATI(3), S. MEHRABI(1), Y. GHANDI(3)


(1)School of Medicine, Arak University of Medical Sciences, Arak, Iran;
(2)Pediatric Oncology, Iran University of Medical Sciences, Tehran, Iran;
(3)Pediatric Oncology, Amir-Kabir Hospital, Arak University of Medical Sciences, Arak, Iran


Abstract:

Background: Pulmonary hypertension is one of the most common cardiac complications among patients with ?-thalassemia major (?-TM). The aim of this study is to investigate the correlation of pulmonary artery pressure (PAP), serum ferritin level, and cardiac T2* MRI in patients with ?-TM. Method: This cross-sectional study was performed on 50 patients older than 7 years old. Echocardiography, electrocardiography, and cardiac T2* MRI were performed on all patients and their serum ferritin levels were measured. Based on the echocardiographic the patients were divided into two groups of PAP>30 and <30 mmHg. Results: 40% had PAP higher than 30 mmHg, 32% had abnormal T2* MRI, and 36% had serum ferritin levels higher than 1500ng/dl. there were significant negative correlations between CMRI *T2 and PAP (-0.36) and the P-pulmonary (-0.29). the serum ferritin level was positively correlated with PAP (0.44) and the P pulmonary in ECG (0.30). in the patients with PAP>30, the means of age, serum ferritin level, and P-pulmonary were significantly higher than patients with PAP<30 (P=0.001). In the patients with PAP>30mmHg, CMRI *T2 had higher accuracy (80%), sensitivity (65%), and specificity (90%) compared to the measurement of serum ferritin levels. Conclusion: The PAP was positively correlated with serum ferritin levels and negatively with T2MRI. The accuracy of 80% for T2MRI as a method to diagnose or even anticipate PH among patients with TM suggested that this method is a useful and accurate method of PH diagnosis and can be used as an alternative among clinicians.


Keywords: ?-Thalassemia Major, Cardiac T2* MRI, Pulmonary Artery Pressure, Serum Ferritin Levels



Corresponding: Yazdan Ghandi, Pediatric Cardiologist, Amir Kabir Hospital, Arak University of Medical Sciences, Arak, Iran, ORCID ID: 0000-0002-8825-7163, Zip code: 3817996647, e-mail: drghandi1351@gmail.com


DOI 10.12865/CHSJ.47.02.06 - Download PDF
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