Curr Health Sci J, vol. 47, no. 2, 2021

Vitamin Status as Predictors in Rheumatoid Arthritis

[Original Paper]

Radu Razvan Mititelu(1), Manuela Violeta Bacanoiu(2), Ana-Maria Buga(3), Vlad Padureanu(4), Andreea Barbulescu(5)


(1)Department of Microbiology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Physical Therapy and Sports Medicine, University of Craiova, Romania,
(3)Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, Romania,
(5)Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Musculoskeletal disorders are the leading cause of long term disability in EU with a significant impact on health care system and with increased social and economic costs. Despite of recent advances in Rheumatoid arthritis (RA) research field, here is still lacking of specific biomarkers that can be used in order to distinguish between different RA patterns and the clinical criteria are still the main tool used only for classification of diseases. Our hypothesis is that the vitamin deficiency associated with chronic inflammation can lead to a mild increase in Hcy level in blood that can act as predictor of increased risk of complication in RA patients. The aim of our study was to identify a correlation between level of Hcy in peripheral blood samples collected from RA patients and to establish if the Hcy level can be validate as potential predictive biomarker in RA patients treated with different DMARDs. Our findings suggest that Hcy level in plasma and CRP are independent predictors of chronic inflammatory status and are useful biomarkers in order to estimate the risk of complication in RA patients. To our knowledge to date, studies before had a controversial findings regarding the efficiency of folate and B12 vitamins supplements on decreasing the cardiovascular events risk. We showed that the folic acid and B12 supplements are important.


Keywords:
Rheumatoid arthritis, homocysteine, vitamin status, inflammation.



Corresponding:
Buga Ana-Maria, Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Petru Rares nr. 2, Craiova, Dolj, Romania, Postal Code 200349, e-mail: ana.buga@umfcv.ro


DOI 10.12865/CHSJ.47.02.07 - Download PDF