Curr Health Sci J, vol. 47, no. 2, 2021

Clostridoides Difficile Infection Severity Assessment by Fecal Calprotectin: A Pilot Study

[Original Paper]

Mirela Nicoleta Voicu(1), Ana Maria Ahmet(2), Adina Turcu-Stiolica(3), Bogdan Silviu Ungureanu(4), Alice Nicoleta Dragoescu(5), Florica Popescu(6)


(1)Phd Student, Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Student, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Pharmacoeconomics, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania,
(5)Department of Anesthesiology University of Medicine and Pharmacy of Craiova, Romania,
(6)Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Clostridoides difficile infection (CDI) is the leading cause of antibiotic related diarrhea therapy and may associate high morbidity and mortality. Providing a potential biomarker to assess disease severity may help physicians in choosing the right treatment. Methods. This was a prospective, single-centre cohort study which included patients diagnosed with CDI which were assessed by fecal calprotectin (FC). Results. Patients included had a mean of 69.29 years of age, 54.23% of male gender. Patients diagnosed with mild CDI had a mean ATLAS score of 3.39 (±1.24), statistically lower (p<0.001) than patients with severe CDI who had a mean ATLAS score of 7.33 (±0.77). Fecal calprotectin concentrations were significantly higher (p<0.001) in the severe CDI patients (615.14μg/g; IQR, 403.62-784.4μg/g) than in the mild CDI patients (195.42μg/g; IQR, 131.12-298.59μg/g). We suggest a cut-off of 290.09μg/g for the predictive marker of fecal calprotectin, which permitted to identify patients with severe and mild CDI, having 100% sensitivity and 76% specificity. Conclusions. Our findings point out the potential that FC might have, as a biomarker for disease severity. However, future multicentre studies and in larger cohort need to validate the results.


Keywords:
Clostridoides difficile infection, fecal calprotectin, predictive value



Corresponding:
Alice Nicoleta Dragoescu, Department of Anesthesiology, University of Medicine and Pharmacy of Craiova, Romania, e-mail: alice.dragoescu@yahoo.com


DOI 10.12865/CHSJ.47.02.09 - Download PDF