Curr Health Sci J, vol. 48, no. 1, 2022

Combination of Pentoxifylline and Ginko Biloba Nephroprotective Effect in Animal Models with Vancomycin-Induced Nephrotoxicity

[Original Paper]

R. Popa(1), M. Diaconu(1), V. Cirlig(1), C. Marius Varu(2), D.C. Caragea(3), R.A. Codea(4), F.A. Tabaran(5), M. Aurori(6), M. Gafencu(7), C.C. Georgescu(1)


(1)Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania
(2)Department of Biophysics, University of Medicine and Pharmacy of Craiova, Romania
(3)Department of Nephrology, University of Medicine and Pharmacy of Craiova, Romania
(4)Department of Internal Medicine, University of Agricultural of science and Veterinary Medicine, Cluj-Napoca, Romania
(5)Department of Anatomic Pathology, University of Agricultural of science and Veterinary Medicine, Cluj-Napoca, Romania
(6)Chemistry Department, University of Agricultural of science and Veterinary Medicine, Cluj-Napoca, Romania
(7)Department of Pediatrics, University of Medicine and Pharmacy “Victor Babes” of Timisoara, Romania


Abstract:

Antioxidants have been commonly used in medicine for thousands of years. Clinically, pentoxifylline and Ginkgo biloba have beneficial renal effects. Our study evaluated the nephroprotective effect of Gingko biloba in combination with Pentoxifiln in an experimental model of vancomycin-induced nephrotoxicity. Male Winstar rats were used in 3 groups: CONTROL, VANCO and VANCO+GBI+PTX and each group included 6 rats. Insufficient studies in the literature on the prevention of acute kidney injury by the combination of Ginkgo biloba and pentoxifylline led to the necessity to perform the study. Acute kidney injury was demonstrated by measuring serum values of classical markers such as urea and creatinine but also by measuring the urinary N-acetyl-?-d-glucosaminidase index, a topical marker in modern medicine. The significant decrease of the biochemical parameters in group III (VANCO+GBI+PTX) compared to group II (VANCO) and values similar to group I (CONTROL), demonstrates, the nephroprotective effect of the use in combination of the two substances.


Keywords:
Acute kidney injure, Vancomycin-induced nephrotoxicity, Pentoxifylline, Ginko Biloba.



Corresponding:
Magdalena Diaconu, Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania, e-mail: diaconumagda @yahoo.com


DOI 10.12865/CHSJ.48.01.10 - Download PDF