CHSJ

Curr Health Sci J, vol. 48, no. 1, 2022

Histopathological Study of the Prostate Cancer Growth Patterns in Relation with the Grading Systems

[Original Paper]

T.C.T. Popescu(1), A.E. Stepan(2), M.M. Florescu(2), C.E. Simionescu(2)


(1)PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Prostate adenocarcinomas are common lesions with a high incidence and variable prognosis, which can be assessed using tumor grading systems. In this study, we analyzed 329 prostate adenocarcinomas in relation to tumor variants, growth patterns, classical and updated grading systems. The study indicated statistical associations of atrophic, pseudohyperplastic and microcystic variants with low grading scores, the associations of glomeruloid, cribriform with or without necrosis and signet ring-like cell variants with high grading scores, and also of single growth patterns with intermediate scores, which supports the accordance and usefulness of existing grading systems for the identification of aggressive prostate tumor lesions.


Keywords: Prostate adenocarcinoma, histological patterns, ISUP groups.



Corresponding: Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.48.01.14 - Download PDF
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