CHSJ

Curr Health Sci J, vol. 48, no. 2, 2022

Biocompatibility Studies on a Collagen-Hydroxyapatite Biomaterial

[Original Paper]

O.L. FILIP IONESCU(1), A.G. MOCANU(1), I.A. NEACSU(2), M.V. CIOCILTEU(1), G. RAU(1), J. NEAMTU(1)


(1)Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania;
(2)Faculty of Appplied Chemistry and Materials Science, Politehnica University of Bucharest, Romania


Abstract:

The current treatment of osteomyelitis includes systemic antibiotic therapy and a debridement procedure of the formed biofilm and necrotic tissue. Moreover, cements and three-dimensional scaffolds are used both for the delivery of therapeutic agents and as fillers for bone defects. The aim of our research was to test, on cellular cultures, the biocompatibility of a previously synthesized microporous biocomposite containing hydroxyapatite and a collagen matrix including a therapeutic agent (ciprofloxacin and gentamicin). The scaffold was obtained by direct mineralization namely co-precipitation of hydroxyapatite on a collagen matrix.


Keywords: Biocomposite, collagen-hydroxyapatite, biocompatibility.



Corresponding: Oana-Liliana Ionescu (Filip), Doctoral School, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rare Street 2, 200349 Craiova, Romania, e-mail: oanaionescu611@yahoo.com; Mocanu Andreea Gabriela department II, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rare Street 2, 200349 Craiova, e-mail: gabriela_deca@yahoo.com


DOI 10.12865/CHSJ.48.02.12 - Download PDF
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