CHSJ

Curr Health Sci J, vol. 48, no. 2, 2022

Prediction of Preterm Birth with Serial Measurements of Ultrasound Markers

[Original Paper]

I.V. CAMEN(1,7), M.M. MANOLEA(2,7), S.C. VRABIE(2,7), M.S. SANDULESCU(2,7), M.S. SERBANESCU(3), M.V. BOLDEANU(4), L. NOVAC(2,7), A.M. ISTRATE-OFITERU(6), S.D. NEAMTU(5,8), A.L. DIJMARESCU(2,7)


(1)Ph.D. student, Doctoral School, University of Medicine and Pharmacology of Craiova, Romania;
(2)Obstetrics and Gynecology Department, University of Medicine and Pharmacology of Craiova, Romania;
(3)Medical Informatics Department, University of Medicine and Pharmacology of Craiova, Romania;
(4)Immunology Department, University of Medicine and Pharmacy of Craiova, Romania;
(5)Department of Hematology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania;
(6)Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
(7)Department of Obstetrics and Gynecology, “Filantropia” Hospital from Craiova;
(8)Department of Clinical Laboratory, “Filantropia” Hospital from Craiova


Abstract:

To compare the ability of cervical length (CL), anterior cervical angle (ACA), and cervical consistency index (CCI) to predict premature birth. Methods. This prospective study involved 85 pregnant women who gave birth prematurely and a control group of 31 pregnant women who gave birth at term. The study was performed in the Obstetrics and Gynecology Clinic of the Municipal Clinical Hospital Filanthropia Craiova between January 1, 2019, and January 1, 2022. Cases were examined using transvaginal ultrasonography (TVU) in the second and third trimesters of pregnancy, and cervical length (CL), Anterior Cervical Angle (ACA), and Cervical Consistency Index (CCI) were measured. Results. The mean value from the three measurements at all three parameters was statistically significant with preterm birth (p<0.05). Cervical length <25mm, was highly significant in the prediction of preterm labor with a sensitivity of 99%, specificity of 61%, positive predictive value (PPV) of 78%, negative predictive value (NPV) of 97 %, and a positive likelihood ratio (LR+) of 2.54 and negative likelihood ratio (LR-) of 0.02. CCI also remains, despite low specificity and PPV values, a potential predictive parameter in the prediction of preterm birth, with a sensitivity of 73%, NPV of 92% and a LR+of 1.32 and LR- of 0.6 also correlated with CL, CCI being more difficult to interpret as an independent predictive parameter. Conclusions. CL remains the standard parameter for predicting the preterm birth, but in combination with other parameters, the prediction rate can increase significantly.


Keywords: Cervical length, anterior cervical angle, cervical consistency index, preterm birth.



Corresponding: Simona Daniela Neamtu, Department of Hematology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Dolj, Romania, e-mail: simona_0712@yahoo.com, Anca-Maria Istrate-Ofiteru, Department of Histology, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Dolj, Romania, e-mail: ancaofiteru92@yahoo.com


DOI 10.12865/CHSJ.48.02.04 - Download PDF
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