CHSJ

Curr Health Sci J, vol. 48, no. 2, 2022

Clinicopathological Prognostic Parameters of Endometrioid Endometrial Carcinomas

[Original Paper]

I. DROCAS(1), S. CRAITOIU(2), A.E. STEPAN(3), I.A. DROCAS(4), M.D. STEPAN(5)


(1)PhD Student, Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Histology, University of Medicine and Pharmacy of Craiova, Romania;
(3)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania;
(4)Department of Urology, University of Medicine and Pharmacy of Craiova, Romania;
(5)Department of Infant Care-Pediatrics-Neonatology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Endometrioid endometrial carcinomas (EEC) are common malignant lesions of the female genital tract, with incidence and risk factors that raise issues to improve histopathological prognostic factors. The study included 50 EEC cases, for which the clinicopathological parameters represented by age, risk factors, tumor grade, histological differences, invasion pattern, tumor stage and association of endometrial hyperplasia were analyzed statistically. The results indicated the predominance of EEC in the 7th decade of life, with associated risk factors (78%), more frequently well differentiated (52%), with no other specifications related to differentiation (NOS, 60%), with irregular invasion pattern (66%) in<50% of the myometrial wall (48%). Irregular pattern, microcystic, elongated, and fragmented (MELF) pattern and myoinvasion associated with vascular invasion (MVI) pattern were significantly associated with high grade and advanced stage tumors. With the exception of EEC-NOS and squamous differentiation, all other tumors were associated with low grade (G1). In this study there was a tendency to associate the age group of 60-69 years with the presence of endometrial hyperplasia and with high grade and advanced stage. Apart from the high grade and advanced stage, in the aggressive profile of the EEC can be included as the clinicopathological parameters the 7th decade of life and the irregular, MELF and MVI invasion patterns.


Keywords: Endometrial endometrioid carcinoma, prognostic parameters, invasion pattern



Corresponding: Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.48.02.08 - Download PDF
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