Curr Health Sci J, vol. 48, no. 3, 2022

Classification and Grading Systems in Gastric Adenocarcinomas

[Original Paper]

O.I. Creu(1), A.E. Stepan(2), C.E. Simionescu(2), D. Marinescu(3), M.D. Stepan(4)


(1)PhD Student, Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of General Surgery, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Infant Care-Pediatrics*Neonatology, University of Medicine and Pharmacy of Craiova, Romania


Abstract:

Gastric adenocarcinomas are lesions that raise important issues in clinical practice, due to their incidence and biological behavior. Over time, various systems have been used for classifying and grading of gastric adenocarcinomas, in the hope of increasing the diagnostic accuracy. In this study we statistically analyzed 112 cases of gastric adenocarcinomas in relation to different classification and grading systems, in order to identify their efficacy and concordance in the histopathological diagnosis. The results indicated a significant association of the Lauren and World Health Organization 2019 classifications and also between these and the three-tier and two-tier grading systems, which supports their practical utility in establishing the diagnosis and assessment of the tumor aggressiveness, for the differentiated therapy.


Keywords:
Gastric adenocarcinomas, histopathological type, degree of differentiation, Lauren classification, WHO classification.



Corresponding:
Alex Emilian Stepan, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania, e-mail: astepan76@yahoo.com


DOI 10.12865/CHSJ.48.03.06 - Download PDF