Curr Health Sci J, vol. 48, no. 3, 2022

Calcium and Phosphorus Deficiencies in Patients with Liver Cirrhosis

[Original Paper]

C.M. Ionele(1), M.S. Subtirelu(2), B.S. Ungureanu(3), M.S. Serbanescu(4), I. Rogoveanu(3)


(1)Ph.D. student, Doctoral School, University of Medicine and Pharmacology of Craiova, Romania,
(2)Department of Pharmacoeconomics, University of Medicine and Pharmacy of Craiova, Romania,
(3)Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania,
(4)Department of Medical Informatics, University of Medicine and Pharmacology of Craiova, Romania


Abstract:

Patients with cirrhosis often develop malnutrition and micronutrient deficiencies, leading to a worse prognosis and increased mortality. Our purpose was to assess the prevalence of micronutrient deficiencies especially calcium and phosphorus in patients with decompensated liver cirrhosis (LC). This was a retrospective study including 143 consecutive patients hospitalized for acute decompensation of cirrhosis, most of them with alcoholic etiology along with viral B or viral C and autoimmune induced cirrhosis. A blood test including minerals was performed on admission. Lower serum calcium levels were found in patients with a more severe forms of LC and also the ones diagnosed with viral and alcoholic LC rather than autoimmune induced LC. Peritoneal ascitic fluid was observed in 51 patients with hypocalcemia and only 24 patients with normal calcium levels had fluid accumulation. Low levels of phosphorus were noted in patients with a more severe form of LC (chi-square: 20.2504; p-value 0.000446). Ascitic fluid was found in patients with low values of phosphorus as well as in those with hypocalcemia (chi-square 5.235; p-value 0.022137). In conclusion, this study confirmed that patients with advanced liver disease had lower values of calcium and phosphorus and a more severe form of LC can be associated with hypocalcemia and hypophosphatemia.


Keywords:
Liver cirrhosis, calcium, phosphorus.



Corresponding:
Mircea-Sebastian Serbanescu, Department of Medical Informatics, University of Medicine and Pharmacology of Craiova, Romania, e-mail: mircea_serbanescu@yahoo.com


DOI 10.12865/CHSJ.48.03.09 - Download PDF